Dosing

Take with food. Do not crush or chew capsules. Individualize dosage and monitor during up-titration. (2)

  • Heart failure: Start at 10 mg once daily and increase to 20, 40, and then 80 mg once daily over intervals of at least 2 weeks. Maintain lower doses if higher doses are not tolerated. (2.1)
  • Left ventricular dysfunction following myocardial infarction: Start at 20 mg once daily and increase to 40 mg then 80 mg once daily after intervals of 3 to 10 days. A lower starting dose or slower titration may be used. (2.2)
  • Hypertension: Start at 20 mg once daily and increase if needed for blood pressure control to 40 mg then 80 mg once daily over intervals of 1 to 2 weeks. (2.3)
  • Elderly patients (>65 years of age): When switching from higher doses of immediate-release carvedilol to COREG CR®, a lower starting dose should be considered to reduce the risk of hypotension and syncope. (2.5)

Dosage Forms and Strengths

Capsules: 10, 20, 40, 80 mg (3)

Dosing Conversion from Immediate-Release

Daily Dose of Immediate-Release Carvedilol TabletsDaily Dose of COREG CR Capsulesa
6.25 mg (3.125 mg twice daily)10 mg once daily
12.5 mg (6.25 mg twice daily)20 mg once daily
25 mg (12.5 mg twice daily)40 mg once daily
50 mg (25 mg twice daily)80 mg once daily

a When switching from carvedilol 12.5 mg or 25 mg twice daily, a starting dose of COREG CR 20 mg or 40 mg once daily, respectively, may be warranted for elderly patients or those at increased risk of hypotension, dizziness, or syncope. Subsequent titration to higher doses should, as appropriate, be made after an interval of at least 2 weeks.